科学研究情况简介 |
【近5年来主要研究课题】 1. 非病毒载体（超分子纳米粒子）用于CRISPR/Cas9基因编辑领域治疗多种单基因疾病包括先天性视网膜裂损症、镰刀型贫血症、地中海贫血症和杜氏肌营养不良症等。 2. 超分子纳米粒子用于药物传输领域，通过纹身的方式在皮内可控释放药物治疗真菌病如甲癣等。 3. 金属二茂钴聚合物的合成 (通过RAFT聚合, ATRP聚合, 和ROP开环聚合等聚合方法)及其在抗菌方面的应用。 【近5年来代表性论文】 1. Peng Yang,‡ Shih-Jie Chou,‡ Jindian Li, Wenqiao Hui, Wenfei Liu, Na Sun, Ryan Y. Zhang, Yazhen Zhu, Matthew Smalley, Jiayuan Chen, Zulema Romero, Dahai Liu, Zunfu Ke, Chang Zou, Chin-Fa Lee, Steve J. Jonas, Qian Ban,* Paul S. Weiss,* Donald B. Kohn,* Kai Chen,* Shi-Hua Chiou* and Hsian-Rong Tseng* Supramolecular Nanosubstrate-Mediated Delivery System Enables CRISPR/Cas9 Knockin of Hemoglobin Beta Gene for Hemoglobinopathies. Science Advances, 2020, 6, eabb7107. 2. Peng Yang, Yuanyuan Luo, Leman B. Kurnaz, Marpe Bam, Xiaoming Yang, Alan W. Decho, Mitzi Nagarkatti, and Chuanbing Tang* Biodegradable Polycaprolactone Metallopolymer-Antibiotic Bioconjugates Containing Phenylboronic Acid and Cobaltocenium for Antimicrobial Application. Biomaterials Science, 2021, 9, 7237-7246. 3. Qian Ban,‡ Peng Yang,‡ Shih-Jie Chou, Li Qiao, Haidong Xia, Jingjing Xue, Fang Wang, Xiaobin Xu, Na Sun, Ryan Y. Zhang, Ceng Zhang, Athena Lee, Wenfei Liu, Ting-Yi Lin, Yu-Ling Ko, Petar Antovski, Xinyue Zhang, Shih-Hwa Chiou, Chin-Fa Lee,* Wenqiao Hui,* Dahai Liu,* Steve J. Jonas,* Paul S. Weiss,* and Hsian-Rong Tseng* Supramolecular Nanosubstrate-Mediated Delivery Strategy for CRISPR/Cas9 Gene Disruption and Deletion. Small 2021, 2100546. (‡Equal contribution) 4. Shih-Jie Chou,‡ Peng Yang,‡ Qian Ban, Yi-Ping Yang, Mong-Lien Wang, Chian-Shiu Chien, Paul S. Weiss,* Hsian-Rong Tseng* and Shi-Hua Chiou* Dual Supramolecular Nanoparticle Vectors Enable CRISPR/Cas9-Mediated Knockin of Retinoschisin 1 Gene—A Potential Nonviral Therapeutic Solution for X-Linked Juvenile Retinoschisis. Advanced Science 2020, 1903432. (‡Equal contribution, highlighted as a Frontispiece,) 5. Fang Wang,‡ Peng Yang,‡ Jin-sil Choi, Petar Antovski, Yazhen Zhu, Xiaobin Xu, Ting-Hao Kuo, Li-En Lin, Diane N.H. Kim, Pin-Cheng Huang, Haoxiang Xu, Chin-Fa Lee, Changchun Wang,* Cheng-Chih Hsu,* Kai Chen,* Paul S. Weiss,* and Hsian-Rong Tseng* Cross-Linked Fluorescent Supramolecular Nanoparticles for Intradermal Controlled Release of Antifungal Drug – A Therapeutic Approach for Onychomycosis. ACS Nano 2018, 12, 6851-6859. (‡Equal contribution) 6. Peng Yang, Paras Pageni, Marpe Bam, Yungpin Chen, Mitzi Nagarkatti, Alan Decho and Chuanbing Tang* Gold Nanoparticles with Antibiotic-Metallopolymers toward Broad-Spectrum Antibacterial Effects.. Advanced Healthcare Materials 2019,8,1800854. 7. Peng Yang, Paras Pageni, Pabel Kabir, Tianyu Zhu and Chuanbing Tang* Metallocene-Containing Homopolymers and Heterobimetallic Block Copolymers via Photo-Induced RAFT Polymerization. ACS Macro Letters 2016, 5, 1293-1300. 8. Peng Yang, Xianfu Luo, Sheng Wang, Fang Wang, and Changchun Wang* Biodegradable Yolk-Shell Microspheres for Ultrasound/MR Dual-Modality Imaging and Controlled Drug Delivery. Colloids and Surfaces B. 2017,15, 333-343. 9. Peng Yang, Marpe Bam, Paras Pageni, Yungpin Chen, Mitzi Nagarkatti, Alan Decho, and Chuanbing Tang* Trio Act of Boronolectin with Antibiotic-Metal Complexed Macromolecules toward Broad-Spectrum Antimicrobial Efficacy. ACS Infectious Diseases, 2017, 3, 845-853. |
