科学研究情况简介 |
【近年来获得的学术科研成果】 近年来主要从事光化学和生物医药的研究，围绕“AIE荧光生物成像——药物缓释和靶向治疗——诊疗一体化”的思路展开了一系列创新性的科学研究。已经在国际学术刊物上发表SCI论文14篇，专利2项。其中以第一作者或共同一作在Angew. Chem. Int. Ed., Chem. Sci., Adv. Mater., J. Med. Chem., Mol. Cancer Ther.等期刊发表论文9篇，他引700余次，1篇入选ESI高被引论文。 【近年来主持的科研项目】 1. 国家自然科学基金-青年（2022-2024），主持 2. 江苏省自然科学基金-青年（2021-2024），主持 3. 第69批全国博士后面上资助（2021-2022），主持 4. 中央高校自主科研计划青年基金（2021-2022），主持 【近年来主要论文代表作】#为共同一作 1. Andong Shao, Qin Xu, Chang Won Kang, Christopher F. Cain, Avery Lee, Chih-Hang Anthony Tang, Juan R. Del Valle, Chih-Chi Andrew Hu, An IRE-1-targeting caged prodrug with ER stress-inducing and XBP-1s-inhibiting activities for cancer therapy, Mol. Pharm., 2022, Accepted. 2. Andong Shao, Qin Xu, Walker T. Spalek, Christopher F. Cain, Chang Won Kang, Chih-Hang Anthony Tang, Juan R. Del Valle, Chih-Chi Andrew Hu, Development of Tumor-specific IRE-1 Inhibitors for B cell Cancer Therapy, Mol. Cancer Ther., 2020, 19, 2432. 3. Andong Shao, Chang Won Kang, Chih-Hang Anthony Tang, Christopher F. Cain, Qin Xu, Claire M. Phoumyvong, Juan R. Del Valle, Chih-Chi Andrew Hu, Structural Tailoring of a Novel Fluorescent IRE‑1 RNase Inhibitor to Precisely Control Its Activity, J. Med. Chem., 2019, 62, 5404. 4. Yan Tang, Andong Shao#, Jun Cao, Hui Li, Qiang Li, Meiying Zeng, Ming Liu, Yingsheng Cheng, Weihong Zhu, cNGR-based Synergistic-targeted NIR Fluorescent Probe for Tracing and Bioimaging of Pancreatic Ductal Adenocarcinoma, Science China Chemistry, 2018, 61, 184. 5. Meiying Zeng, Andong Shao#, Hui Li, Yan Tang, Qiang Li, Zhiqian Guo, Chungen Wu, Yingsheng Cheng, He Tian, Weihong Zhu, Peptide Receptor-Targeted Fluorescent Probe: Visualization and Discrimination between Chronic and Acute Ulcerative Colitis, ACS Applied Materials & Interfaces, 2017, 9, 13029. 6. Yongsheng Li, Andong Shao#, Yao Wang, Ju Mei, Dechao Niu, Jinlou Gu, Ping Shi, Weihong Zhu, He Tian, Jianlin Shi, Morphology Tailoring of a Red AIEgen from Microsized Rods to Nanospheres for Tumor-Targeted Bioimaging, Adv. Mater., 2016, 28, 3187. 7. Andong Shao, Yongshu Xie, Shaojia Zhu, Zhiqian, Guo, Shiqin Zhu, Jin Guo, Ping Shi, Tony D. James, He Tian, Weihong Zhu, Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects, Angew. Chem. Int. Ed. 2015, 54, 7275. 8. Andong Shao, Zhiqian, Guo, Shaojia Zhu, Shiqin Zhu, Ping Shi, He Tian, Weihong Zhu, Insight into Aggregation-induced Emission Characteristics of Red-emissive Quinolinemalononitrile by Cell Tracking and Real-time Trypsin Detection, Chem. Sci. 2014, 5, 1383. |
