科学研究情况简介 |
【近5年来主要研究课题】 [1] 脏器纤维化治疗新靶点的发现及其分子作用机制研究。 [2] 食源性生物活性物质筛选及分子药理机制研究。 【近5年来主持项目】 [1] 国家自然科学基金面上项目，31970746，脱硫弧菌通过肠肝轴诱导肝纤维化的机制研究，2020.01-2023.12。 [2] 国家自然科学基面上项目，31771514，Fstl1在肝纤维化进展和消退过程肝星状细胞命运决定中的作用，2018.01-2021.12。 【近5年来代表性论文】 [1] Geng Y*, Yue Y, Guan Q, Ren Y, Guo L, Fan Y, Lu ZM, Shi JS, Xu ZH*, Cereal Vinegar Sediment Alleviates Spontaneous Ulcerative Colitis in Il-10 Deficient Mice. Molecular Nutrition & Food Research, 2021;65(24):e2001227. [2] Xie XQ, Geng Y*, Guan Q, Ren Y, Guo L, Lv Q, Lu ZM, Shi J, Xu ZH. Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study. Nutrients, 2021, 13, 1008. [3] Ren Y, Li HX, Zhou L, Lu ZM, Shi J, Geng Y*, Xu ZH. Protective Effect of Antrodia camphorata spores powder on CCl4-induced Liver Fibrosis in Mice. Nutrients, 2020, 12(9), 2778. [4] Xu XY, Du Y, Liu X, Ren Y, Dong Y, Xu HY, Shi JS, Jiang D, Xu X, Li L, Xu ZH, Geng Y*. Targeting Follistatin like 1 ameliorates liver fibrosis induced by carbon tetrachloride through TGF-beta1-miR29a in mice. Cell Commun Signal, 2020, 18 (1), 151. [5] Geng Y, Liu X, Liang J, Habiel D M, Vrishika K, Coelho A L, Deng N, Xie T, Wang Y, Liu N, Huang G, Kurkciyan A, Liu Z, Tang J, Hogaboam C M, Jiang D, Noble P W. PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis [J]. JCI Insight, 2019, 4(6):e125326. [6] Jing F, Geng Y*, Xu XY, Xu HY, Shi JS, Xu ZH*. MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H(+) Transporting V1 Subunit C1 [J]. Int J Mol Sci, 2019, 20(4): 796. [7] Ren Y, Geng Y*, Du Y, Li W, Lu ZM, Xu HY, Xu GH, Shi JS, Xu ZH*. Polysaccharide of Hericium erinaceus attenuates colitis in C57BL/6 mice via regulation of oxidative stress, inflammation-related signaling pathways and modulating the composition of the gut microbiota [J]. J Nutr Biochem, 2018, 57:67-76. [8] Geng Y#, Sun Q#, Li W, Lu ZM, Xu HY, Shi JS, Xu ZH. The common dietary flavonoid myricetin attenuates liver fibrosis in carbon tetrachloride treated mice [J]. Mol Nutr Food Res, 2017, 61(4): [9] Geng Y#, Zhu S#, Cheng P, Lu ZM, Xu HY, Shi JS, Xu ZH. Bioassay-guided fractionation of ethyl acetate extract from Armillaria mellea attenuates inflammatory response in lipopolysaccharide (LPS) stimulated BV-2 microglia [J]. Phytomedicine, 2017, 26:55-61. 【近5年主要授权专利】 [1] 耿燕,许正宏,史劲松,陆震鸣,任怡琳,郭琳. 一种具有抗氧化活性的金针菇酸性多糖的制备方法. 发明专利号：ZL 201910339539.2. [2] 许正宏,史劲松,陆震鸣,耿燕,陈露. 一种治疗酒精性肝病的云芝胞内糖肽活性成分PSK-1c1. 发明专利号：ZL 201611186262.7. [3] 许正宏,史劲松,陆震鸣,耿燕,李恒,许泓瑜,徐国华,王英燕, 钱建瑛. 桦褐孔菌液体发酵产物氯仿提取物在制备治疗糖尿病药物中的应用. 发明专利号：ZL 201210530341.0. 【主要奖励】 [1] 2020年，江苏高校“青蓝工程”培养对象优秀青年骨干教师 [2] 2019年，中国商业联合会——全国商业科技进步奖一等奖，药用真菌高效优质液态发酵关键技术及产品开发，（排名1/10） [3] 2016年，中华医学会呼吸病学分会, 高影响力呼吸学术论文奖，排名(3/3) |
