科学研究情况简介 |
【近5年来获得的学术科研成果】 主要研究方向是将动态共价键化学与生物医用材料、酶催化、糖化学相结合，开发动态智能新材料。近年来主持国家自然科学基金、江苏省自然科学基金，荣获江苏省特聘教授、“双创”博士荣誉称号，以第一作者或通讯作者发表SCI文章30余篇，包括专业权威期刊Chemical Reviews、ACS Catalysis、Chemical Communications等，并参与部分本科生教学。 【近5年来主持项目】 江苏省自然科学基金青年项目 国家自然科学基金青年项目 江苏特聘教授项目 江苏省“双创”博士项目 【近5年来代表性论文】 Z. Cai, Y. Yan, J. Zhou, Y. Yang, Y. Zhang,* J. Chen,* Multifunctionalized brush-like glycopolymers with high affinity to P-selectin and antitumor metastasis activity, Biomacromolecules 2021, 22, 1177. H. Cui, Q. Wang, Y. Zhang, M. Barboiu,* Y. Zhang,* J. Chen,* Double-network heparin dynamic hydrogels: dynagels as anti-bacterial 3D cell culture scaffolds, Chem. Eur. J. 2021, 27, 7080. Y. Zhang, Q. Wang, Z. Wang, D. Zhang, J. Gu, K. Ye, D. Su, Y. Zhang,* J. Chen,* M. Barboiu,* Strong, self-healing gelatin hydrogels cross-linked by double dynamic covalent chemistry, ChemPlusChem 2021, 86, 1524. Y. Zhang†, Y. Zhang†, H. Cui, M. Barboiu*, J. Chen*. Dynameric collagen self-healing membranes with high mechanical strength for effective cell growth applications, Chem. Eur. J. 2020, 26, 16994. Y. Zhang, M. Barboiu*, O. Ramstrom*, J. Chen*. Surface-directed selection of dynamic constitutional frameworks as an optimized microenvironment for controlled enzyme activation. ACS. Catal. 2020, 10, 1423. Y. Zhang*, Y. Qi, S. Ulrich*, M. Barboiu*, O. Ramstrom*. Dynamic covalent polymers for biomedical applications. Mater. Chem. Front. 2020, 4, 489. Y. Zhang*, Y. Zhang, O. Ramstrom*. Dynamic covalent kinetic resolution. Catal. Rev. 2020, 62, 66. Y. Liu, Z. Xu, Q. Wang, Y. Jiang, R. Wang, S. Chen, J. Zhu, Y. Zhang*, J. Chen*. Selective regulation of RANKL/RANK/OPG pathway by heparan sulfate through the binding with estrogen receptor β in MC3T3-E1 cells. Int. J. Biol. Macromol. 2020, 161, 1526. M. Si, W. Zhu, Y. Zhang*, M. Barboiu*, J. Chen*. Fluorodynamers displaying tunable fluorescence on constitutional exchanges in solution and at solid film-solution interface, Chem. Eur. J. 2020, 26, 10191. Y. Liu, R. Wang, S. Chen, Z. Xu, Q. Wang, P. Yuan, Y. Zhou, Y. Zhang*, J. Chen*. Heparan sulfate loaded polycaprolactone-hydroxyapatite scaffolds with 3D printing for bone defect repair. Int. J. Biol. Macromol. 2020, 148, 153. Y. Zhang, J. Chen*. Dynamic covalent chemistry in enzyme catalysis. SCIENTIA SINICA Vitae, 2019, 49, 605.Y. Zhang, Y. Li, C. Su, M. Barboiu*. Dynameric frameworks with aggregation-induced emission (AIE) for selective detection of ATP. ChemPlusChem. 2018, 83, 506. Yan Zhang, Eddy Petit, and Mihail Barboiu*. Multivalent dendrimers and their differential recognition of short single-stranded DNAs of various length and sequence. ChemPlusChem. 2018, 83, 354. Y. Zhang, C. T. Supuran, M. Barboiu*, Exponential activation of carbonic anhydrase by encapsulation in dynameric host matrices with chiral discrimination. Chem. Eur. J. 2018, 24, 715. Y. Zhang, M. Barboiu,* Mechanism insight into the constitutional phase change selection of dynameric framework libraries, ACS Omega 2018, 3, 329-333. Y. Zhang, M. Barboiu*. Constitutional dynamic materials - towards natural selection of function. Chem. Rev. 2016, 116, 809. 【近5年主要授权专利】 【主要奖励】 |
